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Muscle Biology Laboratory

Dr. Schenk is an exercise physiologist primarily interested in the regulation of substrate metabolism in skeletal muscle. The scope of his research is aimed at determining the impact of alterations in substrate metabolism, which may be induced via exercise, calorie restriction or inactivity, on important health issues such as obesity, diabetes and advancing age.

Dr. Schenk is also interested in the etiology of fatty infiltration in skeletal muscle in orthopaedic-related injuries, such as rotator cuff tears and lumbar spine pathology.


Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S. p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. JCI Insight. 2022 Jan 11;7(1)doi: 10.1172/jci.insight.141344. PubMed PMID: 34813504; PubMed Central PMCID: PMC8765050.
Dayanidhi S, Buckner EH, Redmond RS, Chambers HG, Schenk S, Lieber RL. Skeletal muscle maximal mitochondrial activity in ambulatory children with cerebral palsy. Dev Med Child Neurol. 2021 Oct;63(10):1194-1203doi: 10.1111/dmcn.14785. Epub 2021 Jan 3. PubMed PMID: 33393083; NIHMSID:NIHMS1711364.
Rieger M, Duran P, Cook M, Schenk S, Shah M, Jacobs M, Christman K, Kado DM, Alperin M. Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles. Ann Biomed Eng. 2021 Aug;49(8):1836-1847doi: 10.1007/s10439-021-02748-5. Epub 2021 Mar 8. PubMed PMID: 33683527; PubMed Central PMCID: PMC8376748.
Kang JH, Park JE, Dagoon J, Masson SWC, Merry TL, Bremner SN, Dent JR, Schenk S. Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle. J Appl Physiol (1985). 2021 Jun 1;130(6):1893-1902doi: 10.1152/japplphysiol.00065.2021. Epub 2021 Apr 22. PubMed PMID: 33886385; PubMed Central PMCID: PMC8285607.
Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13;10(5):e28684doi: 10.2196/28684. PubMed PMID: 33983131; PubMed Central PMCID: PMC8160808.

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Simon Schenk, Ph.D.


Simon Schenk, PhD
UC San Diego School of Medicine
Department of Orthopaedic Surgery
9500 Gilman Drive, Mail Code 0863
La Jolla, CA 92093-0863

Office: (858) 822-0857
Fax: (858) 822-3807
Web: UCSD Profile