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Neuromuscular Bioengineering Laboratory

Our Research Focus

Our lab studies the function, dysfunction, and plasticity of the nervous and muscular systems. We utilize a cross-disciplinary approach at molecular, cellular, and tissue scales to address the following research priorities:

  • To enhance surgical decision-making and the development of physical therapy protocols by understanding relationships between the ultrastructure of peripheral nerves and their mechanical and physiological function.
  • To develop tissue engineering and biomedical device-based strategies for peripheral nerve regeneration.
  • To reveal mechanisms guiding the remodeling of neuromuscular junctions.
  • To elucidate mechanisms underlying the transport and remodeling of the axonal cytoskeleton.
  • To understand mechanical influences on the morphology and function of neurons in the central nervous system.

 

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Publications

Chaves RS, Tran M, Holder AR, Balcer AM, Dickey AM, Roberts EA, Bober BG, Gutierrez E, Head BP, Groisman A, Goldstein LSB, Almenar-Queralt A, Shah SB. Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons. J Neurosci. 2021 Dec 8;41(49):10034-10053. doi: 10.1523/JNEUROSCI.2553-20.2021. Epub 2021 Oct 18. PMID: 34663629; PMCID: PMC8660048.

Gupta RS, Berrellez D, Chhugani N, Luna Lopez C, Maldonado A, Shah SB. Effects of paclitaxel on the viscoelastic properties of mouse sensory nerves. J Biomech. 2021 Jan 22;115:110125. doi: 10.1016/j.jbiomech.2020.110125. Epub 2020 Nov 12. PMID: 33257008.

Byra M, Hentzen E, Du J, Andre M, Chang EY, Shah S. Assessing the Performance of Morphologic and Echogenic Features in Median Nerve Ultrasound for Carpal Tunnel Syndrome Diagnosis. J Ultrasound Med. 2020 Jun;39(6):1165-1174. doi: 10.1002/jum.15201. Epub 2019 Dec 23. PMID: 31868248.

Howarth HM, Kadoor A, Salem R, Nicolds B, Adachi S, Kanaris A, Lovering RM, Brown JM, Shah SB. Nerve lengthening and subsequent end-to-end repair yield more favourable outcomes compared with autograft repair of rat sciatic nerve defects. J Tissue Eng Regen Med. 2019 Dec;13(12):2266-2278. doi: 10.1002/term.2980. Epub 2019 Nov 26. PMID: 31670904.

Foran I, Vaz K, Sikora-Klak J, Ward SR, Hentzen ER, Shah SB. Regional Ulnar Nerve Strain Following Decompression and Anterior Subcutaneous Transposition in Patients With Cubital Tunnel Syndrome. J Hand Surg Am. 2016 Oct;41(10):e343-e350. doi: 10.1016/j.jhsa.2016.07.095. Epub 2016 Aug 12. PMID: 27527251.


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Sameer B. Shah, Ph.D.

Contact

Sameer B. Shah, Ph.D.
Departments of Orthopaedic Surgery & Bioengineering
UC San Diego
9500 Gilman Drive
Mail Code 0863
La Jolla, CA 92093-0863

Office: (858) 822-0720
Fax: (858) 822-3807
Email: sbshah@ucsd.edu
Web: UCSD Research Profile